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Robin Whittle's avatar

(3 of 3) No amount of fussing over vaccines or not, lockdowns, masks, antibiotics, monoclonal antibodies, surgery etc. will properly improve human health as long as the great majority of the population has half or less of the 25-hydroxyvitamin D their immune systems need to function properly.

Significantly higher levels of 25-hydroxyvitamin D, such as with the Coimbra protocol, are also effective at suppressing numerous auto-immune disorders, including MS, psoriasis, rheumatoid arthritis and both cluster headaches and migraine. Please see: https://coimbraprotokoll.de/en/home/, http://www.clusterheadaches.com and https://vitamindstopscovid.info/06-adv/. The mechanisms for this are not understood. The Coimbra protocol doctors refer to their treatment overcoming "vitamin D insensitivity", but no mechanism is proposed.

Most doctors are unaware of this, and so treat these inflammatory diseases with drugs which suppress both the cytotoxic inflammatory responses AND the already inadequate innate and adaptive responses to cancer cells, bacteria, fungi and viruses. In India, where prednisone was over-used in a desperate attempt to save vitamin D deficient patients from dying from COVID-19, the result was frequently a massive black fungal infection in the lungs which killed many who survived COVID-19.

The synopsis of Dr Howard's 606 page book at: https://www.goodreads.com/book/show/144598292-we-want-them-infected does not mention early treatment for COVID-19.

Does he argue against perfectly effective treatments, the best known of which is ivermectin? A few faulty studies have been used to argue that this is ineffective, but this is impossible to reconcile with the great majority of RCTs listed in the "67 ivermectin COVID-19 studies after exclusions" early treatment table at https://c19ivm.org/meta.html.

Does Dr Howard argue against boosting population levels of 25-hydroxyvitamin D to 50 ng/mL or more, for general health and to protect against sepsis, influenza, COVID-19 and numerous other diseases?

Due to general disinterest in simple, unprofitable, nutritional supplements he may not have been aware of this. However, assuming he is reading this substack, he can now understand the need for 50 ng/mL circulating 259OH0D by reading the research articles cited at: https://vitamindstopscovid.info.

Many other early treatments are analyzed at: https://c19early.org.

Vitamin D would be by far the most successful of these if all doctors recognised the need to boost 25(OH)D levels over 50 ng/mL in a few hours, rather than the 4 days or so it takes with a proper bolus dose of vitamin D3, such as 10 mg 400,000 IU. This delay is due to the need for hydroxylation in the liver. A single oral dose of 1 mg (for 70 kg body weight) calcifediol, which _is_ 25-hydroxyvitamin D, goes straight into circulation and raises the level over 50 ng/mL in a few hours.

This is the primary reason for the spectacular results reported in Castillo et al. fully published in August 2020: https://www.sciencedirect.com/science/article/pii/S0960076020302764 . See also the discussion by two MIT computational biologists: https://www.medrxiv.org/content/10.1101/2020.11.08.20222638v2.

Castillo et al.'s RCT involved, primarily, a single oral dose of 0.532 mg calcifediol for newly hospitalised COVID-19 patients. ICU admissions were reduced from 50% to 2% and deaths from 8% to zero.

This article "Effect of Calcifediol Treatment and best Available Therapy versus best Available Therapy on Intensive Care Unit Admission and Mortality Among Patients Hospitalized for COVID-19: A Pilot Randomized Clinical study" should have revolutionized the treatment of COVID-19. It didn't. This is primarily because most doctors, immunologists, virologists, vaccinologists, epidemiologists and public health officials take far too little interest in genuinely simple, safe, effective interventions. They much prefer complex, profitable interventions - including especially vaccines.

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Robin Whittle's avatar

(2 of 3) There is another pervasive form of ill-health which is not so easily corrected. Most doctors are not aware of this and vitamin D researchers take little or no interest in it. Our ancestors, going back over tens of millions of years, and until about a century ago, were ubiquitously infected by multi-cellular parasites, particularly helminths (intestinal worms).

The innate and adaptive immune responses which work well on cancer cells, bacteria, fungi and viruses (which only work properly with at least 50 ng/mL circulating 25-hydroxyvitamin D) are no use against these pathogens, which have billions of cells. The inflammatory immune response evolved to tackle helminths and the like. (Here I am using "inflammatory" to denote outright cell destruction, including potentially our own cells, rather than the healthy recruitment of immune cells to sites of injury or bacterial / viral infection.)

This healthy, anti-parasite, inflammatory immune response is mediated by cells such as eosinophils (the suicide bombers of the immune system) which indiscriminately destroy cells, including potentially our own. Long ago, helminths evolved to exude one or more compounds which down-modulate the inflammatory responses of the host (us and other mammals). Our ancestors (and those of other mammals) countered this by evolving inflammatory responses which are generally excessively aggressive without this down-modulatory influence, so that with these helminthic compounds they are about the right strength.

Now that we, in developed nations, are all dewormed, many of us suffer from a large range of chronic inflammatory, disorders - such as multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, cluster headaches and migraines and neurodegenerative conditions such as Alzheimer's and Parkinson's disease.

The fundamental cause of these problems is lack of helminths, with some people having more trouble due to individual genetic variation.

Low 25-hydroxyvitamin D levels make this very much worse, because the immune system is unable to properly regulate inflammatory responses. See Chauss et al. 2021: https://www.nature.com/articles/s41590-021-01080-3 discussed at: https://vitamindstopscovid.info/00-evi/#chauss. This is "Autocrine vitamin D signaling switches off pro-inflammatory programs of Th1 cells", by a large team of researchers headed by NIH investigators Majid Kazemian and Behdad Afzali. It was published in Nature Immunology in November 2021 and the preprint was available in mid-2020. The preprint alone should have alerted doctors the world over to what they need to do in order to help COVID-19 patients.

Chauss et al. found that Th1 regulatory lymphocytes from the lungs of hospitalised COVID-19 patients were unable to transition from their pro-inflammatory startup program, to their anti-inflammatory shutdown program, despite detecting the signal to do so. The primary or sole reason for this was lack of 25-hydroxyvitamin D, which is needed to run these cells' internal intracrine signaling system, which needs to work for this to be accomplished. (The article refers to autocrine signaling, which is not quite right - it is intracrine, with the receptors inside the cell, rather than on the outside as in autocrine signaling.)

Many types of immune cell rely on 25-hydroxyvitamin D based intracrine and paracrine (to nearby cells) signaling in order for each cell to respond to its changing circumstances.

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