This article, like your https://www.importantcontext.news/p/leaked-brownstone-institute-emails, exemplifies the left-leaning / woke / mainstream, whatever approach of plastering the opponent with derogatory labels rather than debating the merits of their arguments, evidence and actions in detail. "A shadowy dark money group that has been waging information warfare on public health efforts to tackle the COVID-19 pandemic" is a beauty! We Brownstone folks are chuckling about this in our private Twitter/X forum.
It would be much more helpful for you to debate, rather than deride, those you disagree with.
What failings in the cited research, or the discussion of it, do you find in the article I wrote with Simon Goddek about the immune system's need for at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D 25(OH)D: https://brownstone.org/articles/vitamin-d-everything-you-need-to-know/ ?
Without proper vitamin D3 supplementation in quantities 8 or so times the tiny amounts recommended by the U.S. government, most people have only half or less of this. For 70 kg 154 lb body weight without obesity, 0.125 mg vitamin D3 a day, on average (5000 IU /day) will enable most people to attain at least 50 ng/mL circulating 25(OH)D in a few months. Also a single oral dose of 0.014 milligrams calcifediol per kg bodyweight, which is 1mg for average weight adults, will attain these levels in 4 hours. Calcifediol _is_ 25-hydroxyvitamin D. It goes straight into circulation, while a bolus dose of vitamin D3, such as 10 mg (400,000 IU) takes a few days to be hydroxylated in the liver to the circulating 25(OH)D the immune system needs to function. This is rapid boosting of typically disastrously low 25(OH)D levels is the primary reason for the success of the Castillo et al. 2020 randomized control trail with hospitalised COVID-19 patients in Cordoba, Spain: https://www.sciencedirect.com/science/article/pii/S0960076020302764 ICU admissions were reduced from 50% to 2% and deaths from 8% to zero. A preprint by two computational biologists at MIT https://www.medrxiv.org/content/10.1101/2020.11.08.20222638v2 estimates that the great majority of these benefits must have arisen from boosting the patients' 25(OH)D level so rapidly, with the rest coming from the uneven randomization which happened to result in this RCT.
Next we present graphs from a 2013/14 study by doctors at Massachusetts General Hospital which shows the relationship between the risk of post-operative infection and pre-operative 25(OH)D levels: https://jamanetwork.com/journals/jamasurgery/fullarticle/1782085 The 770 patients were all morbidly obese, which reduces the rate at which they can raise their 25(OH)D levels, from any given body weight ratio of ingested or UV-B generated vitamin D3. They had the same Roux-en-Y gastric bypass surgery for weight loss.
There is no reason to believe that people who are suffering from obesity need higher levels of 25(OH) for their immune systems to mount strong responses to the primarily bacterial pathogens which cause these infections. The results were stark. Above 50 ng/mL, the risks of both surgical site infections and hospital acquired infections were about 2.5%. All those patients would have been supplementing vitamin D3 at healthy levels, well in excess of the lousy 0.015 600 IU a day quantity recommended by the U.S. government, unless they had just spent a lot of time outdoors with bare skin exposure to high elevation sunlight, and so generated the vitamin D3 and so 25(OH)D themselves.
For white skinned people, in winter, far from the equator, who are not supplementing vitamin D3, a typical 25(OH)D level is 18 ng/mL. At this level, the risks of each of these two types of infection rose to about 25%. 10 ng/mL is a typical level for those with dark or black skin, who live far from the equator, and who do not supplement vitamin D3. At this level, the risks of each of these two types of infection rises to 40%. This is frank, deadly, immune system dysfunction - and it occurs at 25(OH)D levels which are entirely _normal_ in much of the North American, British and European population.
This would require you to read and evaluate peer-reviewed journal articles and a few preprints. Please tell us about any conclusion we make or inferences we draw which you believe are not consistent with reality.
Likewise, the 2023-01-19 "Roadmap for COVID-19 Congressional Oversight": https://www.heritage.org/health-care-reform/report/forging-post-pandemic-policy-agenda-road-map-covid-19-congressional . I have only glanced at it, but it looks like a reasonable set of expectations to me. What exactly do you think is wrong with it? Who cares whether it came for free on the back of a breakfast cereal box or from organisation funded by goodness-sucking billionaires? Please tell us what is wrong with it.
If you can't abide the sensibilities of reading our article about vitamin D and the immune system at that horribly compromised Brownstone site (and BTW, I call it Brownstone.org - I don't consider it an "Institute"), perhaps you would like to read a more extensive account at my website: https://vitamindstopscovid.info/00-evi/ . I am no billionaire. My wife and I rent our home. I am an electronic technician and computer programmer who has spent a lot of time since the pandemic started raising awareness of the need for 50 ng/mL circulating 25(OH)D for immune system health. My wife and I used to support left politics. As a schoolboy I joined the Melbourne Moratoriums against the Vietnam war. However, we are part of a growing number of people who think that what passes for the left side of politics these days has lost its mind with guilt-mongering identity politics censorious desire.
Please debate the actual issues, rather than deride, demean and attempt to silence people you disagree with. You might find that you actually do agree with at least some of what they say and write.
We all might learn something. For instance, Simon and I might learn something we overlooked, misunderstood, misconstrued, or should have understood better in the wider context. Also, you might realise that the interlocking web of beliefs you regard as true and self-consistent because all members of your tribe believe them, is actually faulty, sometimes in spectacular ways, such as regarding th origin of SARS-CoV-2: https://www.marshall.senate.gov/wp-content/uploads/MWG-FDR-Document-04-11-23-EMBARGOED.pdf More on this at the pages linked to at https://vitamindstopscovid.info/07-origins/ For instance, you can view the recent Select Subcommittee on the COVID-19 Pandemic hearing in which every Democrat (minority) member took no interest at all in the origin of SARS-CoV-2.
BTW, I paid for a month's subscription in order to post this comment. If you want to know more about reality outside your tribal belief bubble, you might allow comments from free subscribers too. That would be less capitalistic and more in favour of the impecunious working class. My Substack https://nutritionmatters.substack.com. has paid subscriptions only because someone offered to pay - so I have one monthly subscriber. All posts are publicly available. Anyone can comment.
I will renew my subscription to ImportantContext,news if you debate matters in detail rather then insult and try to silence your opponents.
This article, like your https://www.importantcontext.news/p/leaked-brownstone-institute-emails, exemplifies the left-leaning / woke / mainstream, whatever approach of plastering the opponent with derogatory labels rather than debating the merits of their arguments, evidence and actions in detail. "A shadowy dark money group that has been waging information warfare on public health efforts to tackle the COVID-19 pandemic" is a beauty! We Brownstone folks are chuckling about this in our private Twitter/X forum.
It would be much more helpful for you to debate, rather than deride, those you disagree with.
What failings in the cited research, or the discussion of it, do you find in the article I wrote with Simon Goddek about the immune system's need for at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D 25(OH)D: https://brownstone.org/articles/vitamin-d-everything-you-need-to-know/ ?
Without proper vitamin D3 supplementation in quantities 8 or so times the tiny amounts recommended by the U.S. government, most people have only half or less of this. For 70 kg 154 lb body weight without obesity, 0.125 mg vitamin D3 a day, on average (5000 IU /day) will enable most people to attain at least 50 ng/mL circulating 25(OH)D in a few months. Also a single oral dose of 0.014 milligrams calcifediol per kg bodyweight, which is 1mg for average weight adults, will attain these levels in 4 hours. Calcifediol _is_ 25-hydroxyvitamin D. It goes straight into circulation, while a bolus dose of vitamin D3, such as 10 mg (400,000 IU) takes a few days to be hydroxylated in the liver to the circulating 25(OH)D the immune system needs to function. This is rapid boosting of typically disastrously low 25(OH)D levels is the primary reason for the success of the Castillo et al. 2020 randomized control trail with hospitalised COVID-19 patients in Cordoba, Spain: https://www.sciencedirect.com/science/article/pii/S0960076020302764 ICU admissions were reduced from 50% to 2% and deaths from 8% to zero. A preprint by two computational biologists at MIT https://www.medrxiv.org/content/10.1101/2020.11.08.20222638v2 estimates that the great majority of these benefits must have arisen from boosting the patients' 25(OH)D level so rapidly, with the rest coming from the uneven randomization which happened to result in this RCT.
Our article starts with a graph from Dror et al. 2022 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069 which shows a stark relationship between severe COVID-19 outcomes and low pre-infection 25(OH)D levels.
Next we present graphs from a 2013/14 study by doctors at Massachusetts General Hospital which shows the relationship between the risk of post-operative infection and pre-operative 25(OH)D levels: https://jamanetwork.com/journals/jamasurgery/fullarticle/1782085 The 770 patients were all morbidly obese, which reduces the rate at which they can raise their 25(OH)D levels, from any given body weight ratio of ingested or UV-B generated vitamin D3. They had the same Roux-en-Y gastric bypass surgery for weight loss.
There is no reason to believe that people who are suffering from obesity need higher levels of 25(OH) for their immune systems to mount strong responses to the primarily bacterial pathogens which cause these infections. The results were stark. Above 50 ng/mL, the risks of both surgical site infections and hospital acquired infections were about 2.5%. All those patients would have been supplementing vitamin D3 at healthy levels, well in excess of the lousy 0.015 600 IU a day quantity recommended by the U.S. government, unless they had just spent a lot of time outdoors with bare skin exposure to high elevation sunlight, and so generated the vitamin D3 and so 25(OH)D themselves.
For white skinned people, in winter, far from the equator, who are not supplementing vitamin D3, a typical 25(OH)D level is 18 ng/mL. At this level, the risks of each of these two types of infection rose to about 25%. 10 ng/mL is a typical level for those with dark or black skin, who live far from the equator, and who do not supplement vitamin D3. At this level, the risks of each of these two types of infection rises to 40%. This is frank, deadly, immune system dysfunction - and it occurs at 25(OH)D levels which are entirely _normal_ in much of the North American, British and European population.
This would require you to read and evaluate peer-reviewed journal articles and a few preprints. Please tell us about any conclusion we make or inferences we draw which you believe are not consistent with reality.
Likewise, the 2023-01-19 "Roadmap for COVID-19 Congressional Oversight": https://www.heritage.org/health-care-reform/report/forging-post-pandemic-policy-agenda-road-map-covid-19-congressional . I have only glanced at it, but it looks like a reasonable set of expectations to me. What exactly do you think is wrong with it? Who cares whether it came for free on the back of a breakfast cereal box or from organisation funded by goodness-sucking billionaires? Please tell us what is wrong with it.
If you can't abide the sensibilities of reading our article about vitamin D and the immune system at that horribly compromised Brownstone site (and BTW, I call it Brownstone.org - I don't consider it an "Institute"), perhaps you would like to read a more extensive account at my website: https://vitamindstopscovid.info/00-evi/ . I am no billionaire. My wife and I rent our home. I am an electronic technician and computer programmer who has spent a lot of time since the pandemic started raising awareness of the need for 50 ng/mL circulating 25(OH)D for immune system health. My wife and I used to support left politics. As a schoolboy I joined the Melbourne Moratoriums against the Vietnam war. However, we are part of a growing number of people who think that what passes for the left side of politics these days has lost its mind with guilt-mongering identity politics censorious desire.
Please debate the actual issues, rather than deride, demean and attempt to silence people you disagree with. You might find that you actually do agree with at least some of what they say and write.
We all might learn something. For instance, Simon and I might learn something we overlooked, misunderstood, misconstrued, or should have understood better in the wider context. Also, you might realise that the interlocking web of beliefs you regard as true and self-consistent because all members of your tribe believe them, is actually faulty, sometimes in spectacular ways, such as regarding th origin of SARS-CoV-2: https://www.marshall.senate.gov/wp-content/uploads/MWG-FDR-Document-04-11-23-EMBARGOED.pdf More on this at the pages linked to at https://vitamindstopscovid.info/07-origins/ For instance, you can view the recent Select Subcommittee on the COVID-19 Pandemic hearing in which every Democrat (minority) member took no interest at all in the origin of SARS-CoV-2.
BTW, I paid for a month's subscription in order to post this comment. If you want to know more about reality outside your tribal belief bubble, you might allow comments from free subscribers too. That would be less capitalistic and more in favour of the impecunious working class. My Substack https://nutritionmatters.substack.com. has paid subscriptions only because someone offered to pay - so I have one monthly subscriber. All posts are publicly available. Anyone can comment.
I will renew my subscription to ImportantContext,news if you debate matters in detail rather then insult and try to silence your opponents.
Child labor and YOUTH tobacco use.